Structural Formula Vector Image
Title: Clomacran
CAS Registry Number: 5310-55-4
CAS Name: 2-Chloro-9,10-dihydro-N,N-dimethyl-9-acridinepropanamine
Additional Names: 2-chloro-9-[3-(dimethylamino)propyl]acridan
Manufacturers' Codes: SKF-14336D
Molecular Formula: C18H21ClN2
Molecular Weight: 300.83
Percent Composition: C 71.87%, H 7.04%, Cl 11.79%, N 9.31%
Literature References: Prepn: C. L. Zirkle, US 3131190 (1964 to SKF). Effect on in vivo histamine metabolism: R. Schayer, M. A. Reilly, Arch. Int. Pharmacodyn. Ther. 203, 123 (1973). Clinical potency in relation to dopamine-binding: P. Seeman et al., Nature 261, 717 (1976). Pharmacology: P. Fowler et al., Arzneim.-Forsch. 27, 866 (1977). Photooxidation study: W. R. Knappe, J. Pharm. Sci. 67, 318 (1978).
Derivative Type: Phosphate
CAS Registry Number: 22199-46-8
Manufacturers' Codes: SKF-14336
Trademarks: Devryl (SK & F); Olaxin (SK & F)
Molecular Formula: C18H21ClN2.H3PO4
Molecular Weight: 398.82
Percent Composition: C 54.21%, H 6.07%, Cl 8.89%, N 7.02%, P 7.77%, O 16.05%
Properties: LD50 in rats, mice (mg/kg): 350, 222 orally (Fowler).
Toxicity data: LD50 in rats, mice (mg/kg): 350, 222 orally (Fowler)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Other Tricyclics.
Status: This monograph has been retired and is no longer subject to revision or update.

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