Structural Formula Vector Image
Title: Clobutinol
CAS Registry Number: 14860-49-2
CAS Name: 4-Chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylbenzeneethanol
Additional Names: p-chloro-a-[2-(dimethylamino)-1-methylethyl]-a-methylphenethyl alcohol; 2-(p-chlorobenzyl)-3-dimethylaminomethyl-2-butanol; 1-p-chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol
Molecular Formula: C14H22ClNO
Molecular Weight: 255.78
Percent Composition: C 65.74%, H 8.67%, Cl 13.86%, N 5.48%, O 6.26%
Literature References: Prepn: GB 898010; Berg, US 3121087 (1962, 1964 both to Thomae). Pharmacology: Engelhorn, Arzneim.-Forsch. 10, 785 (1960). Metabolism: Beisenherz et al., ibid. 19, 79 (1969).
Properties: bp12 179-180°.
Boiling point: bp12 179-180°
Derivative Type: Hydrochloride
CAS Registry Number: 1215-83-4
Manufacturers' Codes: KAT-256
Trademarks: Biotertussin (Lisapharma); Silomat (Thomae)
Molecular Formula: C14H22ClNO.HCl
Molecular Weight: 292.24
Percent Composition: C 57.54%, H 7.93%, Cl 24.26%, N 4.79%, O 5.47%
Properties: Minute crystals, mp 169-170°. Slightly bitter, acidic taste. Numbs the tongue. Sol in water. LD50 in mice (mg/kg): 600 orally; 130 i.p. (Engelhorn).
Melting point: mp 169-170°
Toxicity data: LD50 in mice (mg/kg): 600 orally; 130 i.p. (Engelhorn)
Therap-Cat: Antitussive.
Keywords: Antitussive.

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