Structural Formula Vector Image
Title: Ciprofibrate
CAS Registry Number: 52214-84-3
CAS Name: 2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Additional Names: 2-[4-(2,2-dichlorocyclopropyl)phenoxy]isobutyric acid
Manufacturers' Codes: Win-35833
Trademarks: Ciprol (Sterling); Lipanor (Winthrop); Modalim (Sanofi)
Molecular Formula: C13H14Cl2O3
Molecular Weight: 289.15
Percent Composition: C 54.00%, H 4.88%, Cl 24.52%, O 16.60%
Literature References: Hypolipemic agent, related structurally to clofibrate, q.v. Prepn: D. K. Phillips, DE 2343606 ; idem, US 3948973 (1974, 1976 both to Sterling). Pharmacokinetics in animals and man: C. Davison et al., Drug Metab. Dispos. 3, 520 (1975). Inhibition of cholesterol biosynthesis in rats: A. Arnold et al., Atherosclerosis 32, 155 (1979). Blood levels, distribution, duration of action: J. Edelson et al., ibid. 33, 351 (1979). Metabolic effects: A. Arnold et al., J. Pharm. Sci. 68, 1557 (1979). Teratology study: H. Tuchman-Duplessis et al., Toxicology 12, 1 (1979).
Properties: Pale cream solid from hexane, mp 114-116°.
Melting point: mp 114-116°
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.

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