Butidrine Hydrochloride
Structural Formula Vector Image
Title: Butidrine Hydrochloride
CAS Registry Number: 1506-12-3
CAS Name: 5,6,7,8-Tetrahydro-a-[[(1-methylpropyl)amino]methyl]-2-naphthalenemethanol hydrochloride
Additional Names: a-[(sec-butylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenemethanol hydrochloride; butydrine hydrochloride
Trademarks: Betabloc (Farmasimes); Recetan (Simes)
Molecular Formula: C16H26ClNO
Molecular Weight: 283.84
Percent Composition: C 67.70%, H 9.23%, Cl 12.49%, N 4.93%, O 5.64%
Literature References: b-Adrenergic blocker. Prepn: Ferrari et al., Boll. Chim. Farm. 103, 32 (1964), C.A. 61, 5580d (1964); FR 1390056 (1965 to Holding Ceresia), C.A. 62, 16162d (1965). Pharmacology: R. Ferrini, Arzneim.-Forsch. 18, 48 (1968). Brief review of butidrine and other b-blockers: A. M. Karow et al., Prog. Drug Res. 15, 103-122 (1971).
Properties: Crystals, mp 129-130°. LD50 in mice (mg/kg): 20.2 i.v.; 235 orally (Ferrini).
Melting point: mp 129-130°
Toxicity data: LD50 in mice (mg/kg): 20.2 i.v.; 235 orally (Ferrini)
Therap-Cat: Antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antiarrhythmic.
Status: This monograph has been retired and is no longer subject to revision or update.

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