Brovincamine
Structural Formula Vector Image
Title: Brovincamine
CAS Registry Number: 57475-17-9
CAS Name: (3a,14b,16a)-11-Bromo-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylic acid methyl ester
Additional Names: cis-11-bromovincamine
Molecular Formula: C21H25BrN2O3
Molecular Weight: 433.34
Percent Composition: C 58.20%, H 5.81%, Br 18.44%, N 6.46%, O 11.08%
Literature References: Cerebrovascular agent, vincamine deriv. Prepn: P. Pfaeffli, DE 2458164; idem, US 4146643 (1975, 1979 both to Sandoz). HPLC determn in plasma: R. R. Brodie, L. F. Chasseaud, J. Chromatogr. 228, 413 (1982). Effect on autonomic nervous system in laboratory animals: K. Kushiku et al., J. Pharmacobio-Dyn. 7, 177 (1984). Cardiovascular effects, mechanistic studies: eidem, Clin. Exp. Pharmacol. Physiol. 12, 121 (1985). Mode of action studies: T. Katsuragi et al., Gen. Pharmacol. 15, 43 (1984). Clinical trials in patients with multi-infarct dementia: S. Hagstadius et al., Psychopharmacology 83, 321 (1984).
Properties: Crystals from isopropanol, mp 214° (dec). [a]D20 +8.7° (1% in CHCl3).
Melting point: mp 214° (dec)
Optical Rotation: [a]D20 +8.7° (1% in CHCl3)
 
Derivative Type: Hydrogen fumarate
CAS Registry Number: 84964-12-5
Manufacturers' Codes: BV-26-723
Trademarks: Sabromin (Sandoz); Zabromin (Sandoz)
Molecular Formula: C21H25BrN2O3.C4H4O4
Molecular Weight: 549.41
Percent Composition: C 54.65%, H 5.32%, Br 14.54%, N 5.10%, O 20.38%
Properties: mp 144°. [a]D20 +4.7° (0.388% in H2O).
Melting point: mp 144°
Optical Rotation: [a]D20 +4.7° (0.388% in H2O)
 
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).

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