Structural Formula Vector Image
Title: Benactyzine
CAS Registry Number: 302-40-9
CAS Name: a-Hydroxy-a-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
Additional Names: benzilic acid b-diethylaminoethyl ester; b-diethylaminoethyl benzilate; 2-diethylaminoethyl diphenylglycolate
Molecular Formula: C20H25NO3
Molecular Weight: 327.42
Percent Composition: C 73.37%, H 7.70%, N 4.28%, O 14.66%
Literature References: An antagonist of acetylcholine in the central and peripheral nervous systems. Prepn: Horenstein, Pahlicke, Ber. 71, 1654 (1938); Blicke, Maxwell, J. Am. Chem. Soc. 64, 428 (1942); Hill, Holmes, US 2394770 (1946 to Am. Cyanamid). Toxicity and pharmacodynamics: Fournier, Petit, Therapie 17, 1245 (1962). Metabolism: Eldeson et al., Arch. Int. Pharmacodyn. Ther. 187, 139 (1970). Crystal and molecular structure determn by x-ray diffraction: T. J. Petcher, J. Chem. Soc. Perkin Trans. 2 1974, 1151.
Properties: Crystals, mp 51°.
Melting point: mp 51°
Derivative Type: Hydrochloride
CAS Registry Number: 57-37-4
Manufacturers' Codes: AY-5406-1
Trademarks: Cedad (Recordati); Nutinal (Boots); Parasan; Suavitil (Merck & Co.)
Molecular Formula: C20H25NO3.HCl
Molecular Weight: 363.88
Percent Composition: C 66.01%, H 7.20%, N 3.85%, O 13.19%, Cl 9.74%
Properties: Crystals from acetone, mp 177-178°. Soly in water (25°): 14.9/100 ml. Practically insol in ether.
Melting point: mp 177-178°
Derivative Type: Methobromide
CAS Registry Number: 3166-62-9
Trademarks: Spatomac
Molecular Formula: C20H25NO3.CH3Br
Molecular Weight: 422.36
Percent Composition: C 59.72%, H 6.68%, N 3.32%, O 11.36%, Br 18.92%
Properties: Crystals from alcohol + ether, mp 169-170°.
Melting point: mp 169-170°
Therap-Cat: Antispasmodic.
Keywords: Antimuscarinic; Antispasmodic.

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