Structural Formula Vector Image
Title: Azimilide
CAS Registry Number: 149908-53-2
CAS Name: 1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione
Molecular Formula: C23H28ClN5O3
Molecular Weight: 457.95
Percent Composition: C 60.32%, H 6.16%, Cl 7.74%, N 15.29%, O 10.48%
Literature References: Potassium channel blocker. Prepn: S. S. Pelosi et al., WO 9304061 (1993 to Procter & Gamble); C.-N. Yu et al., US 5462940 (1995 to Norwich Eaton). Clinical pharmacokinetics: A. Corey et al., J. Clin. Pharmacol. 37, 946 (1997). Clinical trial to improve post-infarct survival: A. J. Camm et al., Am. J. Cardiol. 81, Suppl. 6A, 35D (1998). Review of electrophysiologic properties and pharmacology: R. Karam et al., ibid. 40D-46D.
Derivative Type: Dihydrochloride
CAS Registry Number: 149888-94-8
Manufacturers' Codes: NE-10064
Trademarks: Stedicor (Procter & Gamble)
Molecular Formula: C23H28ClN5O3.2HCl
Molecular Weight: 530.88
Percent Composition: C 52.04%, H 5.70%, Cl 20.03%, N 13.19%, O 9.04%
Properties: Crystals from ethanol/water.
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic; Potassium Channel Blocker.

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