Structural Formula Vector Image
Title: Amiton
CAS Registry Number: 78-53-5
CAS Name: S-[2-(Diethylamino)ethyl]phosphorothioic acid O,O-diethyl ester
Additional Names: O,O-diethyl S-(b-diethylamino)ethyl phosphorothiolate
Trademarks: Inferno; Metramac; Tetram
Molecular Formula: C10H24NO3PS
Molecular Weight: 269.34
Percent Composition: C 44.59%, H 8.98%, N 5.20%, O 17.82%, P 11.50%, S 11.91%
Literature References: Prepn: Ghosh, Newman, Chem. Ind. (London) 1955, 118; Fukuto, Stafford, J. Am. Chem. Soc. 79, 6083 (1957); Lorenz, Schrader, US 3082240 (1963 to Bayer). Toxicity studies: Shaffer, West, Toxicol. Appl. Pharmacol. 2, 1 (1960); Frawley et al., ibid. 5, 605 (1963).
Properties: Liquid. bp0.01 76°; bp0.2 110°. nD27 1.4655. LD50 orally in rats: 5.4 mg/kg (Frawley).
Boiling point: bp0.01 76°; bp0.2 110°
Index of refraction: nD27 1.4655
Toxicity data: LD50 orally in rats: 5.4 mg/kg (Frawley)
Derivative Type: Acid oxalate (hydrogen oxalate)
Molecular Formula: C10H24NO3PS.C2H2O4
Molecular Weight: 359.38
Percent Composition: C 40.10%, H 7.29%, N 3.90%, O 31.16%, P 8.62%, S 8.92%
Properties: Crystals from isopropanol + ether, mp 98-99°. LD50 orally in male albino rats: 9 mg/kg (Shaffer, West).
Melting point: mp 98-99°
Toxicity data: LD50 orally in male albino rats: 9 mg/kg (Shaffer, West)
CAUTION: Cholinesterase inhibitor.
Use: Contact insecticide, miticide.
Status: This monograph has been retired and is no longer subject to revision or update.

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