Structural Formula Vector Image
Title: Allopregnane-3b,17a,20b,21-tetrol
CAS Registry Number: 566-41-6
CAS Name: Pregnane-3,17,20,21-tetrol
Additional Names: 3b,17,20b,21-tetrahydroxy-5a-pregnane; 17-(1,2-dihydroxyethyl)androstane-3,17-diol; Reichstein's substance K
Molecular Formula: C21H36O4
Molecular Weight: 352.51
Percent Composition: C 71.55%, H 10.29%, O 18.15%
Literature References: Isoln from adrenal cortex: Steiger, Reichstein, Helv. Chim. Acta 21, 546 (1938). Prepn by reduction of allopregn-17-ene-3,17-diol 3,21-diacetate with osmium tetroxide: Serini et al., Ber. 72, 391 (1939).
Properties: Leaflets from dilute methanol, mp 198-200°. [a]D21 -1.0° (c = 1 in abs ethanol).
Melting point: mp 198-200°
Optical Rotation: [a]D21 -1.0° (c = 1 in abs ethanol)
Derivative Type: 3,20,21-Triacetate
Molecular Formula: C27H42O7
Molecular Weight: 478.62
Percent Composition: C 67.75%, H 8.84%, O 23.40%
Properties: Rods from ether + pentane, mp 179°. [a]D19 +53.2° (c = 1.9 in acetone).
Melting point: mp 179°
Optical Rotation: [a]D19 +53.2° (c = 1.9 in acetone)
Status: This monograph has been retired and is no longer subject to revision or update.

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