Structural Formula Vector Image
Title: Adrafinil
CAS Registry Number: 63547-13-7
CAS Name: 2-[(Diphenylmethyl)sulfinyl]-N-hydroxyacetamide
Additional Names: 2-(benzhydrylsulfinyl)acetohydroxamic acid
Manufacturers' Codes: CRL-40028
Trademarks: Olmifon (Lafon)
Molecular Formula: C15H15NO3S
Molecular Weight: 289.35
Percent Composition: C 62.26%, H 5.23%, N 4.84%, O 16.59%, S 11.08%
Literature References: a-Adrenergic agonist. Prepn, pharmacology: L. Lafon, BE 846880; US 4066686 (1977, 1978 both to Lafon). Mode of action: J. Duteil et al., Eur. J. Pharmacol. 59, 121 (1979); C. Rozé et al., Arch. Int. Pharmacodyn. Ther. 265, 119 (1983). Psychopharmacology in mice: F. A. Rambert et al., J. Pharmacol. 17, 37 (1986).
Properties: Crystals from ethyl acetate-isopropyl alcohol, mp 159-160°. Soly in water <1 g/l. LD50 in mice (mg/kg): <2048 i.p.; 1950 gastric admin (Lafon).
Melting point: mp 159-160°
Toxicity data: LD50 in mice (mg/kg): <2048 i.p.; 1950 gastric admin (Lafon)
Therap-Cat: Treatment of depression.
Keywords: a-Adrenergic Agonist; Antidepressant.

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