8-Hydroxyquinoline
Structural Formula Vector Image
Title: 8-Hydroxyquinoline
CAS Registry Number: 148-24-3
CAS Name: 8-Quinolinol
Additional Names: oxyquinoline; hydroxybenzopyridine; oxybenzopyridine; phenopyridine; oxychinolin; oxine
Molecular Formula: C9H7NO
Molecular Weight: 145.16
Percent Composition: C 74.47%, H 4.86%, N 9.65%, O 11.02%
Literature References: Prepn: Z. H. Skraup, Monatsh. Chem. 1, 316 (1880); 3, 536 (1882); R. H. F. Manske et al., Can. J. Res. 27F, 359 (1949). Toxicity study: Bernstein et al., Toxicol. Appl. Pharmacol. 5, 599 (1963). Review: J. P. Phillips, Chem. Rev. 56, 271-297 (1956). Book: R. G. W. Hollingshead, Oxine and Its Derivatives I-IV (Butterworth, London, 1954/56).
Properties: White crystals or crystalline powder. mp 76°. bp ~267°. Almost insol in water, ether. Freely sol in alc, acetone, chloroform, benzene, aq mineral acids. LD50 i.p. in mice: 48 mg/kg (Bernstein).
Melting point: mp 76°
Boiling point: bp ~267°
Toxicity data: LD50 i.p. in mice: 48 mg/kg (Bernstein)
 
Derivative Type: Sulfate
CAS Registry Number: 134-31-6
Trademarks: Chinosol (Chinosolfabrik)
Molecular Formula: (C9H7NO)2.H2SO4
Molecular Weight: 388.39
Percent Composition: C 55.66%, H 4.15%, N 7.21%, O 24.72%, S 8.26%
Properties: Pale yellow, cryst powder; slight saffron odor; burning taste. mp 175-178°. Freely sol in water; sol in about 100 parts glycerol, slightly in alcohol. Insol in ether.
Melting point: mp 175-178°
 
Derivative Type: Aluminum sulfate
CAS Registry Number: 153-77-5
Trademarks: Nyxolan; Aloxyn
Molecular Formula: C27H24AlN3O15S3
Molecular Weight: 753.67
Percent Composition: C 43.03%, H 3.21%, Al 3.58%, N 5.58%, O 31.84%, S 12.76%
 
Use: As fungistat; chelating agent in determn of trace metal ions. Aluminum sulfate as antiperspirant, deodorant.
Therap-Cat: Antiseptic. Aluminum sulfate as anthelmintic (Nematodes).
Therap-Cat-Vet: THERAP VET (VET): Antiseptic.
Keywords: Antiseptic/Disinfectant; Quinolines.

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