3-Pyridineacetic Acid
Structural Formula Vector Image
Title: 3-Pyridineacetic Acid
CAS Registry Number: 501-81-5
Additional Names: Lioxone; 3PAA
Trademarks: Minedil (Formenti)
Molecular Formula: C7H7NO2
Molecular Weight: 137.14
Percent Composition: C 61.31%, H 5.14%, N 10.21%, O 23.33%
Literature References: Metabolite of nicotine, q.v. Prepn: K. Miescher, H. Kägi, Helv. Chim. Acta 24, 1471 (1941); S. Carboni, Gazz. Chim. Ital. 85, 1194 (1955). Manuf. process: M. Hartmann et al., US 2408020 (1946 to Ciba). Pharmacology: E. Ginoulhiac, L. T. Tenconi, Minerva Med. 51, 1166 (1960). Clinical evaluation as hypocholesteremic: F. Pupita, ibid. 1140. Thermal and photodecarboxylation: F. R. Stermitz, W. H. Huang, J. Am. Chem. Soc. 93, 3427 (1971). Determn in biological fluids by HPLC: G. A. Kyerematen et al., J. Chromatogr. 419, 191 (1987); by thermospray LC-MS: K. T. McManus et al., J. Chromatogr. Sci. 28, 510 (1990).
Properties: Crystals from ethyl acetate or alcohol, mp 144°.
Melting point: mp 144°
NOTE: Often confused with homonicotinic acid, (4-methyl-3-pyridinecarboxylic acid), in early literature.
Therap-Cat: Antilipemic.

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