3-O-Methyldopa
Structural Formula Vector Image
Title: 3-O-Methyldopa
CAS Registry Number: 300-48-1
CAS Name: 3-Methoxy-L-tyrosine
Additional Names: 3-(4-hydroxy-3-methoxyphenyl)-L-alanine; L-3-methoxy-4-hydroxyphenylalanine; OM-dopa; L-3-MTO; OMD
Molecular Formula: C10H13NO4
Molecular Weight: 211.21
Percent Composition: C 56.87%, H 6.20%, N 6.63%, O 30.30%
Literature References: A major metabolite of L-dopa in man and animals, which has a considerably longer biological half-life than L-dopa: Pletscher et al., Brain Res. 4, 106 (1967); Bartholini, Pletscher, J. Pharmacol. Exp. Ther. 161, 14 (1968); Kuruma et al., Eur. J. Pharmacol. 10, 189 (1970). Proposed as a precursor of dopamine via its partial demethylation in the organism: Bartholini et al., Nature 230, 533 (l971); Chalmers et al., Br. J. Pharmacol. 43, 455P (1971); Bartholini et al., Life Sci. 14, 323 (1974). See also Carlsson, Waldeck, Arch. Pharmacol. 272, 441 (l972); Bartholini, Pletscher, ibid. 274, 404 (1972). Metabolic pathways: Bartholini et al., J. Pharmacol. Exp. Ther. 183, 65 (1972). Parkinsonism treatment studies: Calne et al., Clin. Pharmacol. Ther. 14, 386 (1973).

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