2-Thiouracil
Structural Formula Vector Image
Title: 2-Thiouracil
CAS Registry Number: 141-90-2
CAS Name: 2,3-Dihydro-2-thioxo-4(1H)-pyrimidinone
Additional Names: 2-mercapto-4-hydroxypyrimidine; 4-hydroxy-2(1H)-pyrimidinethione; 2-mercapto-4(1H)-pyrimidinone; 6-hydroxy-2-mercaptopyrimidine; 2-mercapto-4-pyrimidone
Trademarks: Deracil
Molecular Formula: C4H4N2OS
Molecular Weight: 128.15
Percent Composition: C 37.49%, H 3.15%, N 21.86%, O 12.48%, S 25.02%
Literature References: Occurs in seeds of Brassica, Cruciferae: Purves, Br. J. Exp. Pathol. 22, 241 (1941). Prepd by condensing ethyl formylacetate with thiourea: Wheeler, Liddle, Am. Chem. J. 40, 550 (1908). Antithyroid activity results from its interference with the iodination of thyroxine precursors: see Maloof, Soodak, Pharmacol. Rev. 15, 72-79 (1963). Inhibition of nucleic acid metabolism: Cardeilhac, Proc. Soc. Exp. Biol. Med. 125, 692 (1967). Toxicology: K. K. Carroll, R. L. Noble, J. Pharmacol. Exp. Ther. 97, 478 (1949).
Properties: Minute, bitter crystals, no definite mp. Very slightly soluble in water (1:2000); practically insol in alcohol, ether, acids. Readily sol in alkaline solns. LD100 i.p. in rats: 1500 mg/kg (Carroll, Noble).
Toxicity data: LD100 i.p. in rats: 1500 mg/kg (Carroll, Noble)
Therap-Cat: Treatment of hyperthyroidism; angina pectoris; congestive heart failure.
Therap-Cat-Vet: Thyroid depressant. In hyperthyroidism and to promote fattening.
Keywords: Antihyperthyroid.

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