SOLUBILITIES
Approximate Solubilities of USP and NF Articles
  Name and Volume, in mL, of Solvent
Solute (1 g) Water Boiling
Water		 Alcohol Chloroform Ether Other
Acenocoumarol 67,000   280 130 1800  
Acetaminophen   20 10     1 N sodium hydroxide, 15
Acetohexamide     230 210    
Acetylcysteine 5   4      
Acetyldigitoxin 6100   62.5 12 >10,000  
Ammonium Alum 7 0.5        
Aluminum Chloride 0.9   4      
Aluminum Sulfate 1          
Amantadine Hydrochloride 2.5   5.1 18   polyethylene glycol 400, 70
Amaranth 15          
Aminocaproic Acid 3         methanol, 450
Aminohippuric Acid 45   50     3 N hydrochloric acid, 5
Aminosalicylate Sodium 2          
Ammonium Carbonate 4          
Amodiaquine Hydrochloride 25   78 >10,000 >10,000 benzene, 10,000
Anethole1     2      
Anileridine >10,000   2 1    
Anileridine Hydrochloride 5   80 >10,000 >10,000  
Antimony Potassium Tartrate 12 3       glycerin, 15
Apomorphine Hydrochloride 50   50     water at 80, 20
Apraclonidine Hydrochloride 34   74 >10,000   methanol, 13; ethyl acetate, >10,000; hexanes, >10,000
Ascorbic Acid 3   40      
Ascorbyl Palmitate >1000   125 >1000 >1000  
Aspirin 300   5 17 10 to 15  
Atropine 460   2 1 25 water at 80, 90
Atropine Sulfate 0.5 2.5 5     glycerin, 2.5
Bendroflumethiazide     23   200  
Benoxinate Hydrochloride 0.8   2.6 2.5 >10,000  
Benzalkonium Chloride (anhydrous)         100 benzene, 6
Gamma Benzene Hexachloride       3.5 40 dehydrated alcohol, 20
Benzethonium Chloride <1   <1 <1 6000  
Benzocaine 2500   5 2 4 almond oil or olive oil, 30–50
Benzoic Acid 300   3 5 3  
Benzonatate <1   <1 <1 <1  
Betadex 54          
Betamethasone 5300   65 325   warm alcohol, 15; methanol, 3
Betamethasone Acetate 2000   9 16    
Betamethasone Sodium Phosphate 2   470 >10,000 >10,000  
Betamethasone Valerate 10,000   16 <10 400  
Bisacodyl >10,000   210 2.5 275  
Boric Acid 18 4 18     boiling alcohol, 6; glycerin, 4
Bromodiphenhydramine Hydrochloride <1   2 2 3500 isopropyl alcohol, 31
Brompheniramine Maleate 5   15 15    
Busulfan           acetone, 45
Butabarbital Sodium 2   7 7000 10,000  
Butamben 7000          
Butylated Hydroxyanisole     4.0 2.0 1.2  
Butylated Hydroxytoluene     4.0 1.1 1.1  
Caffeine (hydrous) 50   75 6 600  
Calcium Chloride 0.7 0.2 4     boiling alcohol, 2
Calcium Gluconate 30 (slowly) 5        
Calcium Hydroxide 630 1300        
Calcium Lactate 20          
Calcium Pantothenate 3          
Calcium Sulfate 375 485        
Camphor 800   1 0.5 1  
Carbinoxamine Maleate <1   1.5 1.5 8300  
Carisoprodol 2083   2.5 2.3   acetone, 2.5
Cephaloridine 5   1000 10,000 10,000  
Cetylpyridinium Chloride 4.5   2.5 4.5    
Chloral Betaine 1   4 >10,000 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Chloral Hydrate 0.25   1.3 2 1.5  
Chlorambucil           acetone, 2
Chloramphenicol 400          
Chlordiazepoxide >10,000   50 6250 130  
Chlorobutanol 125   1     glycerin, 10
Chlorocresol 260   0.4      
Chloroprocaine Hydrochloride 20   100      
Chlorpheniramine Maleate 4   10 10    
Chlorpromazine     3 2 3 benzene, 2
Chlorpromazine Hydrochloride 1   1.5 1.5    
Chlortetracycline Hydrochloride 75   560      
Cholesterol     100 (slowly)     dehydrated alcohol, 50
Citric Acid 0.5   2   30  
Clindamycin Palmitate Hydrochloride     3     ethyl acetate, 9
Clindamycin Phosphate 2.5   >1000 >1000 >1000  
Clioquinol >100,000   3500 120 4500  
Cocaine 600   7 1 3.5 olive oil, 12; liquid petrolatum, 80–100
Cocaine Hydrochloride 0.5   3.5 15    
Codeine 120   2 0.5 50  
Codeine Phosphate 2.5   325     boiling alcohol, 125; water at 80, 0.5
Codeine Sulfate 30   1300     water at 80, 6.5
Colchicine 25       220  
Cortisone Acetate     350 4   acetone, 75; dioxane, 30
Cupric Sulfate 3 0.5 500     glycerin, 3
Cyanocobalamin 80          
Cyclizine Hydrochloride 115   115 75    
Cyproheptadine Hydrochloride 275   35 26   methanol, 1.5
Dehydrocholic Acid     100 35 2200 (15) acetic acid at 15, 135; acetone at 15, 130; benzene at 15, 960; ethyl acetate at 15, 135
Demeclocycline     200     methanol, 40
Demeclocycline Hydrochloride 60         methanol, 50
Denatonium Benzoate 20   2.4 2.9 5000  
Desipramine Hydrochloride 12   14 3.5 >10,000  
Dexamethasone Sodium Phosphate 2          
Dexbrompheniramine Maleate 1.2   2.5 2 3000  
Dexchlorpheniramine Maleate 1.1   2 1.7 2500  
Dextroamphetamine Sulfate 10   800      
Dextromethorphan Hydrobromide 65          
Dextrose 1   100      
Diazepam 333   16 2 39  
Dibucaine 4600   0.7 0.5 1.4  
Dicyclomine Hydrochloride 13   5 2 770 glacial acetic acid, 2
Diethylpropion Hydrochloride 0.5   3 3    
Digitoxin     150 40    
Dihydroergotamine Mesylate 125   90 175 2600  
Dimercaprol 20          
Dimethisterone     3 0.7    
Diphenhydramine Hydrochloride 1   2 2   acetone, 50
Disulfiram >5000   30   15  
Docusate Calcium 3300   >1 >1 >1  
Docusate Sodium 70 (slowly)          
Doxapram Hydrochloride 50          
Doxylamine Succinate 1   2 2 370  
Droperidol 10,000   140 4 500  
Dyclonine Hydrochloride 60   24 2.3 >10,000 hexane, >10,000
Dydrogesterone >10,000   40 2 200  
Echothiophate Iodide 1         dehydrated alcohol, 25; methanol, 3
Edrophonium Chloride 0.5   5      
Enalaprilat 200   >1000     dimethylformamide, 40; methanol, 68
Ephedrine 20   0.2      
Ephedrine Hydrochloride 3   14      
Ephedrine Sulfate 1.3   90      
Epinephrine Bitartrate 3          
Ergotamine Tartrate 500   500      
Erythromycin 1000          
Erythromycin Estolate     20 10   acetone, 15
Estradiol     28 435 150  
Estradiol Cypionate >10,000   40 7 2800  
Estrone     250 (15) 110 (15)   boiling alcohol, 50; boiling chloroform, 80; acetone at 50, 50; boiling acetone, 33; boiling benzene, 145
Estropipate >2000   >2000 >2000 >2000 warm alcohol, 500
Ethacrynic Acid     1.6 6 3.5  
Ether1 12          
Ethyl Vanillin 100 (50)   2      
Ferrous Gluconate 5          
Ferrous Sulfate 1.5 0.5        
Flumethasone Pivalate >10,000   89 350 2800  
Fluocinolone Acetonide >1000   45 25 350  
Fluorometholone >10,000   200 2200 >10,000  
Fluphenazine Enanthate     <1 <1 2  
Fluphenazine Hydrochloride 1.4   6.7      
Flurandrenolide     72 10   methanol, 25
Flurazepam Hydrochloride 2   4 90 5000 methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000
Fluroxene 220          
Fructose     15     methanol, 14
Gentian Violet     10     glycerin, 15
Glyceryl Monostearate       10.0 100.0 methanol, 100; isopropyl alcohol, 33
Glycine 4   1254     water at 50, 2.6; at 75, 1.9; at 100, 1.5
Glycopyrrolate 4.2   30 260 35,000  
Guaifenesin 60–70          
Halazone >1000   140 >1000 >2000  
Haloperidol >10,000   60 15 200  
Heparin Sodium 20          
Histamine Phosphate 4          
Homatropine Hydrobromide 6   40 420    
Hydralazine Hydrochloride 25   500      
Hydrocortisone     40     acetone, 80
Hydrocortisone Acetate     230 200    
Hydrocortisone Sodium Phosphate 1.5          
Hydroflumethiazide >5000   39 >5000 2500  
Hydromorphone Hydrochloride 3          
Hydroquinone 17   4 51 16.5  
Hydroxocobalamin 50   100 10,000 10,000  
Hydroxyzine Hydrochloride 1   4.5 13 >1000  
Hydroxyzine Pamoate >1000   700 >1000 >1000 dimethylformamide, 10; 10 N sodium hydroxide, 3.5
Hyoscyamine Hydrobromide     2.5 1.7 2300  
Hyoscyamine Sulfate 0.5   5      
Ichthammol 10          
Indigotindisulfonate Sodium 100          
Indomethacin     50 30 40  
Iodine 3000   13     carbon disulfide, 4; glycerin, 80
Ipodate Sodium <1   2     dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5
Isoniazid 8   50      
Isopropamide Iodide 50   10 5    
Isopropyl Alcohol <1   <1 <1 <1  
Isoproterenol Hydrochloride 3   50      
Isoproterenol Sulfate 4   >2000 >2000 >2000  
Isoxsuprine Hydrochloride 500   100 >10,000 >10,000 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100
Ketamine Hydrochloride 4   14 60 >10,000 methanol, 6; absolute alcohol, 60
Lactose 5 (slowly) 2.6        
Levorphanol Tartrate 50   120      
Levothyroxine Sodium 700   300      
Lisinopril 10   >10,000 >10,000 >10,000 methanol, 70
Magnesium Hydroxide >10,000   >10,000 >10,000 >10,000  
Magnesium Sulfate 0.8 0.5       glycerin, 1 (slowly)
Mannitol 5.5          
Menadione     60     benzene, 10; vegetable oils, 50
Mesoridazine Besylate 1   11 3 6300  
Methacholine Chloride 1.2   1.7 2.1    
Methacrylic Acid Copolymer           water in methanol (3 in 100), 10; water in alcohol (3 in 100), 10; water in isopropyl alcohol (3 in 100), 10; water in acetone (3 in 100), 10
Methacycline Hydrochloride 100   300 >1000 >1000 0.1 N sodium hydroxide, 25
Methdilazine Hydrochloride 2   2 6 >10,000 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1
Methenamine 1.5   12.5 10 320  
Methenamine Mandelate     10 20 350  
Methimazole 5   5 4.5 125  
Methocarbamol 40 (20)          
Methotrimeprazine 10   10 2   methanol, 10
Methoxyflurane 500   <1 <1 <1  
Methsuximide 350   3 <1 2  
Methyclothiazide >10,000   92.5 >10,000 2700  
Methylbenzethonium Chloride 0.8   0.9 >10,000 0.7  
Methylene Blue 25   65      
Methylergonovine Maleate 100   175 1900 8400  
Methylparaben 400   3   10 water at 80, 50
Methylprednisolone 10,000   100 800 800  
Methylprednisolone Acetate 1500   400 250 1500  
Methylprednisolone Sodium Succinate 1.5   12 >10,000 >10,000  
Methysergide Maleate 200   165 3400 >10,000  
Miconazole >100,000   9.5 2 15 isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3
Miconazole Nitrate 6250   312 525 50,000 isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75
Morphine Sulfate 16   570     alcohol at 60, 240; water at 80, 1
Nalidixic Acid >1000   910 29 >1000  
Neomycin Sulfate 1          
Niacin 60          
Niacinamide 1.5 10 5.5      
Nifedipine >10,000         acetone, 10
Nitrofurazone 4200   590     propylene glycol, 350
Nitromersol >2000   >2000 >2000 >2000  
Norepinephrine Bitartrate 2.5   300      
Norethindrone Acetate >10,000   10 <1 18 dioxane, 2
Nortriptyline Hydrochloride 90   30 20   methanol, 10
Oxandrolone 5200   57 <5 860 acetone, 69
Oxazepam >10,000   220 270 2200  
Oxtriphylline 1          
Oxymetazoline Hydrochloride 6.7   3.6 862    
Oxymetholone >10,000   40 5 82 dioxane, 14
Oxymorphone Hydrochloride 4   100 >1000 >1000 methanol, 25
Oxytetracycline 4150     >10,000 6250 absolute alcohol, 66
Oxytetracycline Calcium >1000   >1000 >1000 >1000 0.1 N sodium hydroxide, 15
Papaverine Hydrochloride 30   120      
Paraldehyde1 10 17        
Paramethasone Acetate       50   methanol, 40
Paromomycin Sulfate <1   >10,000 >10,000 >10,000  
Pectin 20          
Penicillin G Benzathine 5000   65      
Sterile Penicillin G Procaine 250   30 60    
Sterile Penicillin G Sodium 40          
Penicillin V Benzathine 3200   330 42 910 acetone, 37
Penicillin V Potassium     150      
Pentazocine >1000   11 2 42  
Pentazocine Hydrochloride 30   20 4 >10,000  
Pentobarbital >2000   4.5 4.0 10  
Pentolinium Tartrate 0.5   475 >1000 >2000  
Perphenazine     7     acetone, 13
Phenazopyridine Hydrochloride <10 20 59 331 >5000 cold water, 300; glycerin, 100
Phenindamine Tartrate 40   350      
Phenmetrazine Hydrochloride 0.4   2 2    
Phenobarbital 1000   10      
Phenol 15         mineral oil, 70
Phentolamine Mesylate 1   4 700    
Phenylethyl Alcohol 60   <1 <1 <1 alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1
Phenylmercuric Acetate 180   225 6.8 200  
Phenylmercuric Nitrate 600          
Phenylpropanolamine Hydrochloride 1.1   7.4 4100    
Physostigmine Salicylate 75   16 6 250  
Physostigmine Sulfate 4   0.4   1200  
Pilocarpine Hydrochloride 0.3   3 360    
Pilocarpine Nitrate 4   75      
Piminodine Esylate >1000   6 2 >1000  
Pimozide >10,000   1000 10 1000 acetone, 100; methanol, 1000; 0.1 N hydrochloride acid,
>1000
Polyethylene Glycol 1540 1     3   absolute alcohol, 100
Polyethylene Glycol 4000 4   2.5 2    
Potash, Sulfurated 2          
Potassium Acetate 0.5 0.2 3      
Potassium Alum 7 0.3        
Potassium Benzoate 2   75     alcohol solution (9 in 10), 50
Potassium Chloride 2.8 2        
Potassium Citrate 1         glycerin, 2.5
Potassium Gluconate 3          
Potassium Hydroxide 1   3     glycerin, 2.5
Potassium Iodide 0.7 0.5 22     glycerin, 2
Potassium Permanganate 15 3.5        
Potassium Sodium Tartrate 1          
Potassium Sorbate 4.5   35 >1000 >1000  
Pramoxine Hydrochloride       35    
Prednisolone     30 180   acetone, 50
Prednisolone Acetate     120      
Prednisolone Hemisuccinate 4170   6.3 1064 248  
Prednisolone Sodium Phosphate 4         methanol, 13
Prednisone     150 200    
Prilocaine Hydrochloride 3.5   4.2 175    
Primaquine Phosphate 15          
Primidone 2000   200      
Procaine Hydrochloride 1   15      
Prochlorperazine Edisylate 2   1500      
Prochlorperazine Maleate     1200      
Procyclidine Hydrochloride 35   9 6 11,000  
Promazine Hydrochloride 3          
Propoxycaine Hydrochloride 2   10 >10,000 80  
Propoxyphene Napsylate 10,000   15 10    
Propylhexedrine >500   0.4 0.2 0.1  
Propylparaben 2500 400 1.5   3  
Protriptyline Hydrochloride 2   3.5 2.5 >10,000  
Pseudoephedrine Hydrochloride 0.5   3.6 91 7000  
Pyrazinamide 67     135 1000 absolute alcohol, 175; methanol, 72
Pyridoxine Hydrochloride 5   115      
Pyrilamine Maleate 0.5   3 2   absolute alcohol, 15
Pyrimethamine     200 125    
Pyrrocaine Hydrochloride 1.5   12 8    
Quinidine Sulfate 100   10 15    
Quinine Sulfate 500   120      
Reserpine     1800 6    
Resorcinol 1   1      
Rotoxamine Tartrate 10   100 >10,000 >10,000  
Saccharin 290 25 31      
Saccharin Calcium 2.6   4.7      
Saccharin Sodium 1.5   50      
Salicylic Acid 460 15 3 45 3 benzene, 135
Scopolamine Hydrobromide 1.5   20      
Secobarbital           0.5 N sodium hydroxide, 8.5
Selenium Sulfide       161 1667  
Sennosides 35   2100 3700 6100  
Silver Nitrate 0.4 0.1 30     boiling alcohol, 6.5
Simethicone2 >10,000     102 102 benzene, 102; absolute alcohol, >10,000
Sodium Acetate 0.8 0.6 19      
Sodium Ascorbate 1.3          
Sodium Benzoate 2   75     90 percent alcohol, 50
Sodium Bicarbonate 12          
Sodium Bisulfite 4          
Sodium Borate 16 1       glycerin, 1
Sodium Carbonate 3 1.8        
Sodium Chloride 2.8 2.7       glycerin, 10
Sodium Citrate (hydrous) 1.5 0.6        
Sodium Fluoride 25          
Sodium Formaldehyde Sulfoxylate 3.4   510 175 180  
Sodium Hydroxide 1          
Sodium Iodide 0.6   2     glycerin, 1
Sodium Lauryl Sulfate 10          
Sodium Nitrite 1.5          
Sodium Phosphate, Dried 8          
Sodium Propionate 1 0.65 24 >10,000 >10,000  
Sodium Thiosulfate 0.5          
Sorbic Acid 1000   10 15 30 absolute alcohol, 8; methanol, 8; propylene glycol, 19
Sorbitol 0.45          
Stanozolol >1000   41 74 370  
Stearic Acid     20 2 3  
Stibophen 1   >10,000 >10,000 10,000  
Succinylcholine Chloride 1   350      
Sucrose 0.5 0.2 170      
Sucrose Octaacetate 1100   11     acetone, 0.3; benzene, 0.6; toluene, 0.5
Sulconazole Nitrate 3333   100 333   pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000
Sulfacetamide Sodium 2.5          
Sulfadiazine 13,000         human serum at 37, 620
Sulfadiazine Sodium 2          
Sulfadimethoxine     200     2 N hydrochloric acid, 50
Sulfaethidole >3000   75 1300 1700 methanol, 51; acetone, 13; benzene, 2277
Sulfamethizole 2000   38 1900 1900 acetone, 13
Sulfamethoxazole 3400   50 1000 1000 carbon disulfide, 2 (slowly and usually incompletely)
Sulfapyridine 3500   440     acetone, 65
Sulfasalazine >10,000   2900 >10,000 >10,000 methanol, 1500
Sulfisoxazole 7700         boiling alcohol, 10
Sulfisoxazole Acetyl     176 35 1064 methanol, 203
Precipitated Sulfur           carbon disulfide, 2 (slowly and usually incompletely); olive oil, 100
Tartaric Acid 0.8 0.5 3   250 methanol, 1.7
Terpin Hydrate 200 35 13 140 140 boiling alcohol, 3
Testolactone 4050          
Testosterone       2 100 absolute alcohol, 6
Tetracaine >1000   5 2 2  
Tetracycline 2500   50      
Tetracycline Hydrochloride 10   100      
Tetrahydrozoline Hydrochloride 3.5   7.5 >1000 >1000  
Theophylline Sodium Glycinate 6          
Thiamine Hydrochloride 1   170      
Thiamine Mononitrate 44          
Thiethylperazine Maleate 1700   530 >10,000 >10,000  
Thimerosal 1   12      
Thioguanine     7700      
Thiotepa 13   8.3 1.9 4.1  
Thiothixene >10,000     2 120 absolute alcohol, 110
Thiothixene Hydrochloride 8     280 >10,000 absolute alcohol, 270
Thymol 1000   1 1 1.5 olive oil, 2
Tolazoline Hydrochloride <1   2 3 >10,000  
Triamcinolone Diacetate     13 80   methanol, 40
Triamterene           formic acid, 30; 2-methoxyethanol, 85
Triazolam >10,000   1000 25 >10,000 0.1 N hydrochloric acid, 600
Trichlormethiazide 1100   48 5000 1400 dioxane, 9.1; dimethylformamide, 4.35
Trichloroethylene >10,000          
Triethylenemelamine 2.5   13 3.6   methanol, 8; acetone, 9.5; benzene, 18
Trifluoperazine Hydrochloride 3.5   11 100    
Triflupromazine Hydrochloride <1   <1 1.7    
Trimeprazine Tartrate 2   20 5 1800  
Trimethobenzamide Hydrochloride 2   59 67 720  
Trioxsalen     1150 84   methylenedichloride, 43; 4-methyl-2-pentanone, 100
Tripelennamine Hydrochloride 1   6 6   acetone, 350
Triprolidine Hydrochloride 2.1   1.8 1 2000  
Tromethamine 1.8   45.5 >10,000    
Tubocurarine Chloride 20   45      
Urea 1.5   10     boiling alcohol, 1
Vanillin 100         glycerin, 20; water at 80, 20
Xylometazoline Hydrochloride 35          
Zinc Acetate 2.5   30      
Zinc Chloride 0.5   1.5     glycerin, 2
Zinc Sulfate 0.6         glycerin, 2.5
1  Solubility data for compounds that ordinarily are liquids at 25 are expressed in terms of the ratio of the volume of solute to the volume of solvent; i.e., 1 mL dissolved in mL of solvent.
2  Liquid phase only; silicon dioxide remains as a residue in these solvents.