Magnesium Salicylate
(mag nee' zee um sa lis' i late).
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C14H10MgO6·4H2O 370.59

Magnesium, bis(2-hydroxybenzoato-O1,O2)-, tetrahydrate.
Magnesium salicylate (1:2), tetrahydrate [18917-95-8].

Anhydrous 298.54 [18917-89-0].
» Magnesium Salicylate contains not less than 98.0 percent and not more than 103.0 percent of C14H10MgO6·4H2O.
Packaging and storage— Store in tight containers.
USP Reference standards 11
USP Magnesium Salicylate RS Click to View Structure
USP Salicylic Acid RS Click to View Structure
A: Infrared Absorption 197K: previously dried at 105 for 4 hours.
B: Ultraviolet Absorption 197U
Solution: 20 µg per mL.
Medium: water.
C: It responds to the test for Magnesium 191.
Water, Method I 921: between 17.5% and 21.0%.
Magnesium content— Transfer about 800 mg, accurately weighed, to a 200-mL volumetric flask. Dissolve in and dilute with water to volume, and mix. Stir the resulting solution continuously for about 15 minutes and filter, discarding the first 10 mL of the filtrate, into a flask. Transfer 50.0 mL of the filtrate to a 250-mL conical flask, add 50 mL of water, 5 mL of ammonia–ammonium chloride buffer TS, and 0.15 mL of eriochrome black TS, and titrate with 0.05 M edetate disodium VS to a blue endpoint. Each mL of 0.05 M edetate disodium is equivalent to 1.215 mg of magnesium: between 6.3% and 6.7% of magnesium is found.
Assay— Transfer 3.0 mL of the filtrate prepared in the test for Magnesium content to a 500-mL volumetric flask, dilute with water to volume, and mix. Concomitantly determine the absorbances of this solution and a solution of USP Salicylic Acid RS in water having a known concentration of about 18 µg per mL, in 1-cm cells at the wavelength of maximum absorbance at about 296 nm, with a suitable spectrophotometer, using water as the blank. Calculate the quantity, in mg, of C14H10MgO6·4H2O in the Magnesium Salicylate taken in the test for Magnesium content by the formula:
(370.59 / 276.24)(33.3C)(AU / AS)
in which 370.59 is the molecular weight of magnesium salicylate tetrahydrate; 276.24 is twice the molecular weight of salicylic acid; C is the concentration, in µg per mL, of USP Salicylic Acid RS in the Standard solution; and AU and AS are the absorbances of the test solution and the Standard solution, respectively.
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Topic/Question Contact Expert Committee
Monograph Clydewyn M. Anthony, Ph.D.
Senior Scientific Liaison
(SM22010) Monographs - Small Molecules 2
Reference Standards RS Technical Services
USP35–NF30 Page 3754