Chloramphenicol Oral Solution
» Chloramphenicol Oral Solution is a solution of Chloramphenicol in a suitable solvent. It contains one or more suitable buffers and preservatives. It has a potency of not less than 90.0 percent and not more than 120.0 percent of the labeled amount of C11H12Cl2N2O5.
Packaging and storage— Preserve in tight containers.
Labeling— Label it to indicate that it is for veterinary use only and that it is not to be used in animals raised for food production.
USP Reference standards 11
USP Chloramphenicol RS Click to View Structure
Identification— Prepare a Test solution containing 20 µg per mL chloramphenicol from Oral Solution diluted with water. The ultraviolet absorption spectrum of the Test solution exhibits maxima and minima only at the same wavelength as that of a similar solution of USP Chloramphenicol RS, concomitantly measured.
pH 791: between 5.0 and 8.5, when diluted with an equal volume of water.
Assay— Proceed as directed under Antibiotics—Microbial Assays 81, using an accurately measured volume of Oral Solution diluted quantitatively and stepwise with water to yield a Test Dilution having a concentration assumed to be equal to the median dose level of the Standard.
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Topic/Question Contact Expert Committee
Monograph Morgan Puderbaugh, B.S.
Associate Scientific Liaison
(SM32010) Monographs - Small Molecules 3
Reference Standards RS Technical Services
USP35–NF30 Page 2609