Butyl Alcohol
(bue' til al' ka hol).
DEFINITION
Butyl Alcohol is n-butyl alcohol.
IMPURITIES
• Butyl Ether
Sample:
Butyl Alcohol
Chromatographic system
Mode:
GC
Detector:
Thermal-conductivity detector
Column:
6-mm × 2-m stainless steel column packed with 25% liquid phase G29 3,3¢-thiodipropionitrile on 30- to 40-mesh support S1C
Column temperature:
85
Carrier gas:
Helium
Flow rate:
75 mL/min
Injection size:
10 µL
Analysis
Sample:
Sample
[Note—The retention times for butyl ether, 2-butanol, water, isobutyl alcohol, and butyl alcohol are approximately 6.0, 12.0, 17.0, 18.0, and 25.0 min, respectively. ]
Acceptance criteria:
The response due to butyl ether is NMT 0.2% of the sum of all of the responses.
SPECIFIC TESTS
• Specific Gravity 
841
:
0.807–0.809
841:
0.807–0.809
• Distilling Range, Method II 721:
Butyl Alcohol distills within a range of 1.5, including 117.7.
721:
Butyl Alcohol distills within a range of 1.5, including 117.7.
• Acidity
Sample:
74 mL (60 g)
Analysis:
Titrate the Sample with 0.020 N alcoholic potassium hydroxide, using phenolphthalein TS as the indicator, until a pink color persists for NLT 15 s
Acceptance criteria:
NMT 2.5 mL is consumed
• Water Determination, Method I 921:
NMT 0.1%
921:
NMT 0.1%
• Limit of Nonvolatile Residue
Sample:
100 mL
Analysis:
Evaporate the Sample in a tared porcelain dish on a steam bath, and dry at 105 for 30 min
for 30 min
Acceptance criteria:
The weight of the residue does not exceed 4 mg (0.004%).
• Aldehydes
Sample:
10 mL
Analysis:
To 10 mL of silver-ammonia-nitrate TS in a test tube add the Sample, and mix. Allow the mixture to stand in a dark place for 30 min
Acceptance criteria:
No color is produced, although a slight precipitate may form at the interface of the two layers.
ADDITIONAL REQUIREMENTS
• Packaging and Storage:
Preserve in tight containers, and prevent exposure to excessive heat.
Auxiliary Information—
Please check for your question in the FAQs before contacting USP.
| Topic/Question | Contact | Expert Committee |
|---|---|---|
| Monograph | Robert H. Lafaver, M.S.
Scientific Liaison 1-301-816-8335 |
(EXC2010) Monographs - Excipients |
USP35–NF30 Page 1717