» Trichloromonofluoromethane contains not less than 99.6 percent and not more than 100.0 percent of CCl3F, calculated on the anhydrous basis.
Packaging and storage Preserve in tight cylinders, and avoid exposure to excessive heat.
Identification The IR absorption spectrum of it, determined in a 10-cm cell with sodium chloride windows, at atmospheric pressure, exhibits maxima, among others, at the following wavelengths, in µm: 4.67 (m), 5.95 (m), 7.28 (s), 8.06 (m), 9.2 (vs), 10.7 (vs), 11.8 (vs), and 13.4 (m). The stronger maxima are best obtained at pressures less than 10 mm of mercury.
Boiling temperature: approximately 24, determined as directed under Approximate Boiling Temperature (see Aerosols, Nasal Sprays, Metered-Dose Inhalers, and Dry Powder Inhalers 601).
Water: not more than 0.001%, determined as directed under Water Content (see Aerosols, Nasal Sprays, Metered-Dose Inhalers, and Dry Powder Inhalers 601 and Method Ic under Water Determination 921).
High-boiling residues: not more than 0.01%, determined as directed for High-Boiling Residues, Method I, under Aerosols, Nasal Sprays, Metered-Dose Inhalers, and Dry Powder Inhalers 601.
Chromatographic purity In the chromatogram recorded for the Assay, identify the peaks due to dichlorodifluoromethane and dichlorotetrafluoroethane from relative retention times observed on chromatographing the Resolution preparation: the sum of these two peak areas is not greater than 0.2% of the total of all peak areas; and the sum of the areas of all peaks other than that for trichloromonofluoromethane is not greater than 0.4% of the total of all peak areas.
Inorganic chlorides Place 5 mL of anhydrous methanol in a test tube, add 3 drops of a saturated solution of silver nitrate in anhydrous methanol, shake, and add 7 g of Trichloromonofluoromethane: no opalescence or turbidity is produced.
Resolution preparation and Chromatographic systemProceed as directed in the Assay under Dichlorodifluoromethane.
Assay preparation Introduce the liquid phase of Trichloromonofluoromethane into an evacuated headspace vial.
Procedure Inject the gas phase headspace Assay preparation into the chromatograph, record the chromatogram, and measure the peak areas. Calculate the percentage (a/a) of CCl3F in the portion of Trichloromonofluoromethane taken.
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USP32NF27 Page 1371Pharmacopeial Forum: Volume No. 27(1) Page 1825
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.