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C9H14O6 218.21

1,2,3-Propanetriol triacetate.
Glyceryl triacetate [102-76-1].
» Triacetin contains not less than 97.0 percent and not more than 100.5 percent of C9H14O6, calculated on the anhydrous basis.
Packaging and storage— Preserve in tight containers.
B: The solution prepared as directed in the Assay responds to the tests for Acetate 191.
Specific gravity 841: not less than 1.152 and not more than 1.158.
Refractive index 831: not less than 1.429 and not more than 1.430.
Acidity— Dilute 25 g of Triacetin, accurately weighed, with 50 mL of neutralized alcohol, add 5 drops of phenolphthalein TS, and titrate with 0.020 N sodium hydroxide: not more than 1.0 mL of 0.020 N sodium hydroxide is required for neutralization.
Water, Method I 921: not more than 0.2% is found.
Assay— Transfer about 1 g of Triacetin, accurately weighed, to a 250-mL boiling flask, add 50.0 mL of 0.5 N alcoholic potassium hydroxide VS, connect the flask to a water-jacketed condenser, and reflux on a steam bath for 45 minutes, swirling frequently. Cool, add 5 drops of phenolphthalein TS, and titrate the excess alkali with 0.5 N hydrochloric acid VS. Perform a blank determination (see Residual Titrations under Titrimetry 541). Each mL of 0.5 N alcoholic potassium hydroxide is equivalent to 36.37 mg of C9H14O6.
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Topic/Question Contact Expert Committee
Monograph Behnam Davani, Ph.D., M.B.A.
Senior Scientist
(MDAA05) Monograph Development-Antivirals and Antimicrobials
Reference Standards Lili Wang, Technical Services Scientist
USP32–NF27 Page 3780