Acetic Acid

Acetic acid.
Acetic acid [64-19-7].
» Acetic Acid is a solution containing not less than 36.0 percent and not more than 37.0 percent, by weight, of C2H4O2.
Packaging and storage— Preserve in tight containers.
Identification— It responds to the tests for Acetate 191.
Nonvolatile residue— Evaporate 20 mL in a tared porcelain dish on a steam bath, and dry at 105 for 1 hour: the weight of the residue does not exceed 1.0 mg (0.005%).
Chloride— Add 5 drops of silver nitrate TS to 10 mL of a solution (1 in 10): no opalescence is produced.
Sulfate— Add 5 drops of barium chloride TS to 10 mL of a solution (1 in 10): no turbidity is produced.
Heavy metals 231 To the residue obtained in the test for Nonvolatile residue add 8 mL of 0.1 N hydrochloric acid, warm gently until solution is complete, dilute with water to 100 mL, and use 10 mL of the solution: the limit is 0.001%.
Readily oxidizable substances— Dilute 4.0 mL in a glass-stoppered vessel with 20 mL of water, and add 0.30 mL of 0.10 N potassium permanganate: the pink color is not changed to brown at once, and the liquid does not become entirely brown or free from a pink tint in less than 30 seconds.
Assay— Place about 6 mL of Acetic Acid in a tared, glass-stoppered flask, and weigh accurately. Add 40 mL of water, then add phenolphthalein TS, and titrate with 1 N sodium hydroxide VS. Each mL of 1 N sodium hydroxide is equivalent to 60.05 mg of C2H4O2.
Auxiliary Information— Please check for your question in the FAQs before contacting USP.
Topic/Question Contact Expert Committee
Monograph Feiwen Mao, M.S.
(MDOOD05) Monograph Development-Ophthalmics Oncologics and Dermatologicals
USP32–NF27 Page 1151
Chromatographic Column—
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.