Hydrochloric acid [7647-01-0].
» Hydrochloric Acid contains not less than 36.5 percent and not more than 38.0 percent, by weight, of HCl.
Packaging and storage Preserve in tight containers.
Identification It responds to the tests for Chloride 191.
Residue on ignition 281 To 20 mL add 2 drops of sulfuric acid, evaporate to dryness, and ignite: not more than 2 mg of residue remains (about 0.008%).
Bromide or iodide, Free bromine or chlorine, Sulfate, and Sulfite Dilute it with 2 volumes of water, to perform the following tests.
Bromide or iodide Add 1 mL of chloroform to 10 mL of the dilution, and cautiously add, dropwise, with constant agitation, chlorine TS that has been diluted with an equal volume of water: the chloroform remains free from even a transient yellow, orange, or violet color.
Free bromine or chlorine Add 1 mL of potassium iodide TS and 1 mL of chloroform to 10 mL of the dilution, and agitate the mixture: the chloroform remains free from any violet coloration for at least 1 minute.
Sulfate To a mixture of 3 mL of the dilution and 5 mL of water add 5 drops of barium chloride TS: neither turbidity nor precipitate appears within 1 hour.
Sulfite On the completion of the test for Sulfate, the addition to the liquid of 2 drops of 0.1 N iodine produces neither turbidity nor decolorization of the iodine.
Heavy metals 231 Evaporate 3.4 mL (4 g) on a steam bath to dryness, add 2 mL of 1 N acetic acid to the residue, then dilute with water to 25 mL: the limit is 5 ppm.
Assay Place about 3 mL of Hydrochloric Acid in a glass-stoppered flask, previously tared while containing about 20 mL of water, and weigh again to obtain the weight of the substance under assay. Dilute with about 25 mL of water, add methyl red TS, and titrate with 1 N sodium hydroxide VS. Each mL of 1 N sodium hydroxide is equivalent to 36.46 mg of HCl.
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USP32NF27 Page 1249
Chromatographic columns text is not derived from, and not part of, USP 32 or NF 27.