美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Abacavir Sulfate	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Abacavir Sulfate/Dolutegravir Sodium/Lamivudine	Tablet	II (Paddle)	85	0.01 M Phosphate Buffer with 0.5% sodium dodecyl sulfate (SDS), pH 6.8	900	Abacavir and lamivudine: 10, 15, 20, 30 and 45; Dolutegravir: 5,15, 25, 35 and 45.	2015/05/28
Abacavir Sulfate/Dolutegravir Sodium/Lamivudine	Tablet (For Suspension)	II (Paddle)	50	0.01 M Phosphate Buffer with 0.5 mM EDTA, pH 6.8	500	5, 10, 15, 30, 45 and 60	2023/10/06
Abacavir Sulfate/Lamivudine	Tablet	II (Paddle)	75	0.1 N HCl	900	10, 20, 30, and 45	2007/01/03
Abacavir Sulfate/Lamivudine/Zidovudine	Tablet	II (Paddle)	75	0.1 N HCl	Acid Stage: 900 mL; Buffer Stage: 1000 mL	5, 10, 15, 30 and 45	2007/01/03
Abemaciclib	Tablet	II (Paddle)	75	0.01 N HCl	900	5, 10, 15, 20 and 30	2017/11/16
Abiraterone Acetate	Tablet	II (Paddle)	50	0.25% SLS in 56.5 mM phosphate buffer, pH 4.5	900	10, 20, 30, 45 and 60	2013/02/28
Abrocitinib	Tablet	II (Paddle) with peak vessels	55	Citrate-phosphate buffer, pH 3.5	900	10, 20, 30 and 45	2023/05/18
Acalabrutinib	Capsule	II (Paddle)	50	0.1 N HCl	900	10, 15, 20 and 30	2023/08/17
Acamprosate Calcium	Tablet (Delayed Release)	I (Basket)	180	Acid Stage: 0.1 N HCl Buffer Stage: "Citrate-sodium hydroxide" buffer pH 6.8 (150 ml of 2N NaOH, 21.014 gm of citric acid and ultra-pure water to 1000 ml) (Method B)	Media 1: 750 mL pH 1.1±0.1; Media 2: 950 mL pH 6.0±0.1; Media 3: 1000 mL pH 7.5±0.1	120 (Acid) 30, 60, 90, 120, and 180 (buffer)	2005/12/20
Acarbose	Tablet			Develop a dissolution method			2023/09/15
Acarbose	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Acetaminophen	Suppository	II (Paddle)	50	Phosphate buffer, pH 5	900	15, 30, 45, 60 and 90	2006/08/17
Acetaminophen	Tablet (Extended Release)			Refer to USP			2011/03/03
Acetaminophen/Aspirin/Caffeine	Tablet			Develop a dissolution method			2024/01/03
Acetaminophen/Butalbital	Tablet			Develop a dissolution method			2023/09/15
Acetaminophen/Butalbital/Caffeine	Tablet			Develop a dissolution method			2024/01/03
Acetaminophen/Butalbital/Caffeine/Codeine Phosphate	Capsule			Develop a dissolution method			2023/09/15
Acetaminophen/Caffeine/Dihydrocodeine Bitartrate	Capsule			Develop a dissolution method			2023/09/15
Acetaminophen/Caffeine/Dihydrocodeine Bitartrate	Tablet			Develop a dissolution method			2023/09/15