*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM7630000
CHEMICAL NAME           : Piperidine, 2-(2,2-diphenyl-1,3-dioxolan-4-yl)-,
                          hydrochloride, d-
CAS REGISTRY NUMBER     : 631-06-1
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C20-H23-N-O2.Cl-H
MOLECULAR WEIGHT        : 345.90
WISWESSER LINE NOTATION : T6MTJ B- DT5O COTJ BR& BR &GH -D
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * CL-911C
   * Dexoxadrol hydrochloride
   * d-Dioxadrol hydrochloride
   * d-2-(2,2-Diphenyl-1,3-dioxolan-4-yl)piperidine hydrochloride
   * d-2,2-Diphenyl-4-(2-piperidyl)-1,3-dioxolane hydrochloride
   * NSC-526062
   * Relane
   * U-22,559A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
   Behavioral - analgesia
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 118,352,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 153,105,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 153,105,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 33 mg/kg
TOXIC EFFECTS :
   Behavioral - anticonvulsant
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 153,105,1965
 
                            *** END OF RECORD ***