*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM6499500
CHEMICAL NAME           : Piperidine,
                          4-(2-chloro-9H-xanthen-9-ylidene)-1-methyl-,
                          methanesulfonate
CAS REGISTRY NUMBER     : 60086-22-8
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C19-H18-Cl-N-O.C-H4-O3-S
MOLECULAR WEIGHT        : 407.94
WISWESSER LINE NOTATION : T C666 BO IYJ FG IU- DT6N DYTJ A1 &WSQ1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 4(2-Chloro-9H-xanthen-9-ylidene)-1-methylpiperidine methanesulfonate
   * Clopipazan mesylate
   * SKF-69,634
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 9140 ug/kg/28D
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - excitement
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,15,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 319 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - excitement
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,15,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - excitement
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,15,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 57 mg/kg
TOXIC EFFECTS :
   Behavioral - wakefulness
   Behavioral - excitement
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,15,1981
 
                            *** END OF RECORD ***