*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM6128245
CHEMICAL NAME           : 3-Piperidinecarboxylic acid,
                          1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)-, (R)-
CAS REGISTRY NUMBER     : 115103-54-3
LAST UPDATED            : 199801
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C20-H25-N-O2-S2.Cl-H
MOLECULAR WEIGHT        : 412.04
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)-3-piperidinecarboxylic acid 
    hydrochloride
   * (R)-N-(4,4-Di-(3-methylthien-2-yl)but-3-enyl)nipecotic acid hydrochloride
   * NNC-05-0328
   * NO 328
   * Tiagabine
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 630 mg/kg/21D-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   EPIRE8 Epilepsy Research.  (Elsevier Science Publishers B.V., POB 1527, 1000
   BM, Amsterdam, Netherlands)  V.1-    1987-  Volume(issue)/page/year:
   19,205,1994
 
                            *** END OF RECORD ***