*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM4962000
CHEMICAL NAME           : 1-Piperidinebutanoic acid,
                          8-(1,2-dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethy
                          l-2-
                          (2-propynyl)-2H-(1)benzopyrano(4,3-c)pyridin-10-yl
                          ester, monohydrochloride
CAS REGISTRY NUMBER     : 49637-08-3
LAST UPDATED            : 199107
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C35-H52-N2-O3.Cl-H
MOLECULAR WEIGHT        : 585.35
WISWESSER LINE NOTATION : T B666 DN IO HHT&&J D2UU1 H1 H1 LY1&Y5&1 NOV3- AT6NTJ
                          &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Abbott 40656
   * BPP
   * Nabutan
   * NIB
   * SP 106
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 19,454,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 570 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   5,439,1980
 
                            *** END OF RECORD ***