*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM4960200
CHEMICAL NAME           : 1-Piperidinebutanamide,
                          4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha
                          -diphenyl-, 1-oxide, (E)-
CAS REGISTRY NUMBER     : 106900-12-3
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C29-H33-Cl-N2-O3
MOLECULAR WEIGHT        : 493.09
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Loperamide N-oxide
   * trans-N-Oxide of loperamide
   * R 58425
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 172 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 8,279,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 8,279,1986
 
                            *** END OF RECORD ***