*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM4728640
CHEMICAL NAME           : Piperidine, 4-(N-benzylanilino)-1-methyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 1229-69-2
LAST UPDATED            : 199706
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C19-H24-N2.Cl-H
MOLECULAR WEIGHT        : 316.91
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(N-Benzylanilino)-1-methylpiperidine hydrochloride
   * 1-Methyl-N-phenyl-N-(phenylmethyl)-4-piperidinamine hydrochloride
   * 4-Piperidinamine, 1-methyl-N-phenyl-N-(phenylmethyl)-, hydrochloride
   * Soventol hydrochloride
   * Taumidrine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,393,1961
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 75,1148,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 75,1148,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DMWOAX Deutsche Medizinische Wochenschrift.  (Stuttgart, Fed. Rep. Ger.)
   V.1-104, 1875-1979.  Volume(issue)/page/year: 75,1148,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 189 mg/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,393,1961
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22750 mg/kg/26W-C
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,393,1961
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 3360 mg/kg/4W-C
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   3,393,1961
 
                            *** END OF RECORD ***