*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM2785200
CHEMICAL NAME           : Piperazine and sodium nitrite (4:1)
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
WISWESSER LINE NOTATION : T6M DMTJ 4 &.NA..N-O2
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Sodium nitrite and piperazine (1:4)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 gm/kg/47W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   IGSBDO Izvestiya Akademii Nauk Gruzinskoi SSR, Seriya Biologicheskaya.
   Proceedings of the Academy of Sciences of the Georgian SSR, Biological
   Series.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1975-
   Volume(issue)/page/year: 5,321,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 183 gm/kg/28W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   46,1029,1971
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 gm/kg/39W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   IGSBDO Izvestiya Akademii Nauk Gruzinskoi SSR, Seriya Biologicheskaya.
   Proceedings of the Academy of Sciences of the Georgian SSR, Biological
   Series.  (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1975-
   Volume(issue)/page/year: 5,321,1979
 
                            *** END OF RECORD ***