*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM2663170
CHEMICAL NAME           : 1-Piperazinepropanol,
                          4-(8-chloro-10,11-dihydro-2-fluorodibenzo(b,f)thiepin
                          -10-yl)-, (Z)-2-butenedioate (1:1)
LAST UPDATED            : 198702
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C21-H24-Cl-F-N2-O-S.C4-H4-O4
MOLECULAR WEIGHT        : 523.06
WISWESSER LINE NOTATION : T C676 BS&T&J FG I- AT6N DNTJ D3Q& MF &QV1U1VQ -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   4-(8-Chloro-10,11-dihydro-2-fluorodibenzo(b,f)thiepin-10-yl)-1-piperazin
     epropanol maleate
   *   8-Chloro-2-fluoro-10-(4-(3-hydroxypropyl)piperazino)-10,11-dihydrodibenz
     o(b,f)thiepin maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 148 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,719,1975
 
                            *** END OF RECORD ***