*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TM2663150
CHEMICAL NAME           : 1-Piperazinepropanol,
                          4-(2-chloro-10,11-dihydro-7-fluorodibenzo(b,f)thiepin
                          -10-yl)-, (Z)-2-butenedioate (1:1)
CAS REGISTRY NUMBER     : 58722-70-6
LAST UPDATED            : 198702
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C21-H24-Cl-F-N2-O-S.C4-H4-O4
MOLECULAR WEIGHT        : 523.06
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   4-(2-Chloro-10,11-dihydro-7-fluorodibenzo(b,f)thiepin-10-yl)-1-piperazin
     epropanol maleate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 553 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,2887,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 112 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - ataxia
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,2887,1975
 
                            *** END OF RECORD ***