*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL2833500
CHEMICAL NAME           : Piperazine, 1-(3-chlorophenyl)-, monohydrochloride
CAS REGISTRY NUMBER     : 13078-15-4
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C10-H13-Cl-N2.Cl-H
MOLECULAR WEIGHT        : 233.16
COMPOUND DESCRIPTOR     : Human
SYNONYMS/TRADE NAMES :
   * 1-(m-Chlorophenyl)piperazine hydrochloride
   * 1-(3-Chlorophenyl)piperazine hydrochloride
   * 1-(3-Chlorophenyl)piperazine monohydrochloride
   * Piperazine, 1-(m-chlorophenyl)-, monohydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Behavioral - headache
   Gastrointestinal - nausea or vomiting
REFERENCE :
   CLPTAT Clinical Pharmacology and Therapeutics (St. Louis).  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1960-
   Volume(issue)/page/year: 43,605,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 142 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 17(Suppl 5),S1247,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - pleural thickening
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 17(Suppl 5),S1247,1989
 
                            *** END OF RECORD ***