*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL4310000
CHEMICAL NAME           : Piperazine,
                          1-(10,11-dihydro-8-(methylthio)dibenzo(b,f)thiepin-10
                          -yl)-4-methyl-, (+-)-
CAS REGISTRY NUMBER     : 20229-30-5
BEILSTEIN REFERENCE NO. : 0626221
REFERENCE               : 5-23-02-00468 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H24-N2-S2
MOLECULAR WEIGHT        : 356.58
WISWESSER LINE NOTATION : T C676 BS&T&J FS1 I- AT6N DNTJ D1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dibenzo(b,f)thiepin,  
   10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)- (+-)
   *   (+-)-1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylp
     iperazine
   * Methiothepin
   *   (+-)-10-(4-Methylpiperazinyl)-8-(methylthio)-10,11-dihydrodibenzo(b,f)th
     iepin
   *   (+-)-8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiep
     in
   * Metitepine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   2,250,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   2,250,1977
 
                            *** END OF RECORD ***