*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL4240000
CHEMICAL NAME           : Piperazine,
                          1-(10,11-dihydro-8-fluorodibenzo(b,f)thiepin-10-yl)-4
                          -methyl-, maleate (1:1)
CAS REGISTRY NUMBER     : 19939-33-4
LAST UPDATED            : 198707
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H21-F-N2-S.C4-H4-O4
MOLECULAR WEIGHT        : 444.56
WISWESSER LINE NOTATION : T C676 BS&T&J FF I- AT6N DNTJ D1 &QV1U1VQ -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dibenzo(b,f)thiepin, 10,11-dihydro-8-fluoro-10-(4-methylpiperazino)-,  
   hydrogen maleate
   * 8-Fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin maleate
   * Fluothepin maleate
   * VUFB6.271
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 138 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 41,881,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ACNSAX Activitas Nervosa Superior.  (Avicenum, Malostranske nam. 28, Prague
   1, Czechoslovakia) V.1-    1959-  Volume(issue)/page/year: 9,422,1967
 
                            *** END OF RECORD ***