*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL1900000
CHEMICAL NAME           : Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-,
                          hydrochloride
CAS REGISTRY NUMBER     : 18719-22-7
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C17-H19-Cl-N2.xCl-H
MOLECULAR WEIGHT        : 542.05
WISWESSER LINE NOTATION : T6N DNTJ DYR&R DG &GH
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Norchlorcyclizine hydrochloride
   * Piperazine, 1-(alpha-(4-chlorophenyl)benzyl)-, hydrochloride
   * Piperazine, 1-((4-chlorophenyl)phenylmethyl)-, hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 192 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,199,1978
 
                            *** END OF RECORD ***