*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL1761600
CHEMICAL NAME           : Piperazine,
                          1-(8-chloro-10,11-dihydro-3-fluorodibenzo(b,f)thiepin
                          -10-yl)-4-methyl-, (Z)-2-butenedioate (1:1)
LAST UPDATED            : 198704
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H20-Cl-F-N2-S.C4-H4-O4
MOLECULAR WEIGHT        : 479.00
WISWESSER LINE NOTATION : T C676 BS&T&J EF J- AT6N DNTJ D1& MG &QV1U1VQ -C
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   8-Chloro-3-fluoro-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiep
     in maleate
   * 3-Fluorooctoclothepin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37600 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,719,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29700 ug/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 40,719,1975
 
                            *** END OF RECORD ***