*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TL0280000
CHEMICAL NAME           : Piperazine,
                          1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl
                          )-, dihydrochloride
CAS REGISTRY NUMBER     : 129-74-8
LAST UPDATED            : 199701
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C28-H33-Cl-N2.2Cl-H
MOLECULAR WEIGHT        : 506.00
WISWESSER LINE NOTATION : T6N DNTJ AYR&R DG& D1R DX1&1&1 &GH 2
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Aphilan R
   * Buclizine dihydrochloride
   * Buclodin
   * 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine  
   dihydrochloride
   * 1-(p-tert-Butylbenzyl-4-p-chloro-alpha-phenylbenzyl)piperazine  
   dihydrochloride
   * 1-(p-Chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediamine  
   dihydrochloride
   * 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride
   * Histabutyzine dihydrochloride
   * Longifene
   * Softran
   * UCB 4445
   * Vibazine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2100 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,653,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 430 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,653,1954
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 360 mg/kg
SEX/DURATION            : female 10-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 95,109,1966

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***