*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK9700000
CHEMICAL NAME           : Piperazine,
                          1,4-bis((2-methoxy-4-propylphenoxy)acetyl)-
CAS REGISTRY NUMBER     : 154-82-5
BEILSTEIN REFERENCE NO. : 0772468
REFERENCE               : 5-23-01-00074 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C28-H38-N2-O6
MOLECULAR WEIGHT        : 498.68
WISWESSER LINE NOTATION : T6N DNTJ AV1OR D3 BO1& DV1OR D3 BO1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * AP 2
   * 1,4-Bis((2-methoxy-4-propylphenoxy)acetyl)piperazine
   * Kyorin AP 2
   * Simetride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1025 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,206,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 85,715,1965
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical,
   Medical and Dental Supply Exporters' Assoc.,  1968 Volume(issue)/page/year:
   -,84,1968
 
                            *** END OF RECORD ***