*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK8045000
CHEMICAL NAME           : Piperazine,
                          1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahyd
                          ro-2-furanyl)carbonyl )-, monohydrochloride
CAS REGISTRY NUMBER     : 63074-08-8
LAST UPDATED            : 199503
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H25-N5-O4.Cl-H
MOLECULAR WEIGHT        : 423.95
SYNONYMS/TRADE NAMES :
   * Abbott-45975
   * Terazosin hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 277 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 7,435,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4650 mg/kg/31D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Nutritional and Gross Metabolic - body temperature decrease
   Related to Chronic Data - death
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 7,435,1984
 
                            *** END OF RECORD ***