*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK9188600
CHEMICAL NAME           : Piperazine,
                          1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)
                          -, (E)-
CAS REGISTRY NUMBER     : 52468-60-7
LAST UPDATED            : 199206
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C26-H26-F2-N2
MOLECULAR WEIGHT        : 404.54
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * (E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine
   * Flunarizine
   * Sibelium
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 4286 ug/kg/30D-I
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   NEURAI Neurology.  (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1951-  Volume(issue)/page/year: 37,881,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 18 mg/kg/90D-I
TOXIC EFFECTS :
   Behavioral - tremor
REFERENCE :
   NEURAI Neurology.  (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1951-  Volume(issue)/page/year: 37,881,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 37,1103,1987
 
                            *** END OF RECORD ***