*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TK7912030
CHEMICAL NAME           : Piperazine,
                          1-(3-(3-acetyl-4-(p-chlorophenyl)piperidino)propyl)-4
                          -methyl-, trihydrochloride
CAS REGISTRY NUMBER     : 39426-77-2
LAST UPDATED            : 198812
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H32-Cl-N3-O.3Cl-H
MOLECULAR WEIGHT        : 487.39
WISWESSER LINE NOTATION : T6N DNTJ A1 D3- AT6NTJ CV1 DR BG &GH 3
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Acetyl-4-(3-chlorophenyl)-1-(3-(4-methylpiperazino)-propyl)piperidine  
   trihydrochloride
   * 1-(3-(3-Acetyl-4-(p-chlorophenyl)piperidino)propyl)-4-methylpiperazine  
   trihydrochloride
   * S 5
   * Trojchlorowodorek  
   4-acetylo-4-(3-chlorofenylo)-1-(3-(4-metylopiperazyno)-propylo)-piperydy  
   ny
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2290 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 37,579,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2694 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 37,579,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 148 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - analgesia
REFERENCE :
   APPHAX Acta Poloniae Pharmaceutica.  For English translation, see APPFAR.
   (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland)  V.1-    1937-
   Volume(issue)/page/year: 37,579,1980
 
                            *** END OF RECORD ***