*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TK3325000
CHEMICAL NAME : Pimaricin
CAS REGISTRY NUMBER : 7681-93-8
LAST UPDATED : 199801
DATA ITEMS CITED : 27
MOLECULAR FORMULA : C33-H47-N-O13
MOLECULAR WEIGHT : 665.81
WISWESSER LINE NOTATION : T3-25- BO DV SOV IU KU MU OU UUTJ EVQ FQ R1 C&YQ1Q
C&Q HO- BT5OTJ CQ DZ EYQ1
COMPOUND DESCRIPTOR : Agricultural Chemical
Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Antibiotic A-5283
* CL 12,625
* Delvocid
* Delvolan
* Delvopos
* Mycophyt
* Myprozine
* Natacyn
* Natamycin
* Pimafucin
* Pimarizin
* Tennecetin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2730 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
8,97,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 85 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 190 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 36 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 128 mg/kg
TOXIC EFFECTS :
Behavioral - tolerance
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,517,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
QJDRAZ Quarterly Journal of Crude Drug Research. (Lisse, Netherlands)
V.1-19, 1961-81. For publisher information, see IJCREE.
Volume(issue)/page/year: 8,1274,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,639,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 16,1461,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 18 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : >300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1420 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
8,97,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 68 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 180 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 20 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 5,878,1957/1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 90 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 160 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 130 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 9,406,1959
TYPE OF TEST : LD30 - Lethal Dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 2,954,1978
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 34104 mg/kg/2Y-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
8,97,1966
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7 gm/kg/2W-I
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher
information, see AMACCQ. Volume(issue)/page/year: 5,878,1957/1958
** MUTATION DATA **
TYPE OF TEST : Sex chromosome loss and nondisjunction
TEST SYSTEM : Mold - Aspergillus nidulans
DOSE/DURATION : 30 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 79,169,1980
*** END OF RECORD ***