*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TJ7875000
CHEMICAL NAME : Picric acid
CAS REGISTRY NUMBER : 88-89-1
LAST UPDATED : 199712
DATA ITEMS CITED : 41
MOLECULAR FORMULA : C6-H3-N3-O7
MOLECULAR WEIGHT : 229.12
WISWESSER LINE NOTATION : WNR BQ CNW ENW
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* Acide picrique
* Acido picrico
* Carbazotic acid
* C.I. 10305
* 2-Hydroxy-1,3,5-trinitrobenzene
* Kyselina pikrova
* Melinite
* Nitroxanthic acid
* Phenol trinitrate
* Phenol, 2,4,6-trinitro-
* Picric acid
* Picronitric acid
* Pikrinezuur
* Pikrinsaeure
* Pikrynowy kwas
* 2,4,6-Trinitrofenol
* 2,4,6-Trinitrofenolo
* 1,3,5-Trinitrophenol
* 2,4,6-Trinitrophenol
* 2,4,6-Trinitrophenyl
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - chromodacryorrhea
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 37,313,1992
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 56300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
56,450,1960
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 60 mg/kg
TOXIC EFFECTS :
Cardiac - pulse rate
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 271,151,1941
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 271,151,1941
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 umol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 90,91,1981
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 1800 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Oral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1250 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 90,91,1981
TYPE OF TEST : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE : Parenteral
TEST SYSTEM : Insect - Drosophila melanogaster
DOSE/DURATION : 1500 ppm
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 7,677,1985
*** REVIEWS ***
ACGIH TLV-TWA 0.1 mg/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 47,75,1978
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.1 mg/m3 (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,212,1971
OSHA PEL (Gen Indu):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.1 mg/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.1 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993
OEL-BELGIUM:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993
OEL-DENMARK:TWA 0.1 mg/m3;Skin JAN 1993
OEL-FINLAND:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993
OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993
OEL-GERMANY:TWA 0.1 mg/m3;Skin JAN 1993
OEL-HUNGARY:TWA 0.1 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg/m3;Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.1 mg/m3;Skin JAN 1993
OEL-POLAND:TWA 0.1 mg/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.1 mg/m3;STEL 0.2 mg/m3;Skin JAN 1993
OEL-TURKEY:TWA 0.1 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.1 mg/m3;STEL 0.3 mg/m3;Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PICRIC ACID-air:TWA 0.1 mg/m3 (Sk);STEL 0.3 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 59450
No. of Facilities: 2097 (estimated)
No. of Industries: 17
No. of Occupations: 14
No. of Employees: 21627 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 59450
No. of Facilities: 2224 (estimated)
No. of Industries: 20
No. of Occupations: 26
No. of Employees: 37003 (estimated)
No. of Female Employees: 21627 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
*** END OF RECORD ***