*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TJ5363000
CHEMICAL NAME           : 4-Picoline, 2-amino-, hydrochloride
CAS REGISTRY NUMBER     : 32654-41-4
LAST UPDATED            : 199606
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C6-H8-N2.xCl-H
MOLECULAR WEIGHT        : 363.38
WISWESSER LINE NOTATION : T6NJ BZ D1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Ascensil hydrochloride
   * 4M2AP hydrochloride
   * 4-Methyl-2-pyridinamine hydrochloride
   * 2-Pyridinamine, 4-methyl-, hydrochloride
   * RA 1226 hydrochloride
   * VMI 20-4
   * W 45 hydrochloride
   * W 45 Raschig hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 5,125,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 380 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 27 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : >120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >30 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FMTYA2 Farmatsiya (Sofia).  (Hemus, Blvd. Russki 6, Sofia, Bulgaria)  V.1-
   1951-  Volume(issue)/page/year: 23(5),65,1973
 
                            *** END OF RECORD ***