*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TJ4100000
CHEMICAL NAME           : Picolinaldehyde, 1,6-dihydro-1-methyl-, oxime,
                          hydrochloride
CAS REGISTRY NUMBER     : 57619-29-1
LAST UPDATED            : 198706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C7-H10-N2-O.Cl-H
MOLECULAR WEIGHT        : 174.65
WISWESSER LINE NOTATION : T6N BHJ A1 F1UNQ &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 1-Methyl-1,6-dihydropicolinaldehyde oxime hydrochloride
   * N-Methyl-1,6-dihydropyridine-2-carbaldoxime hydrochloride
   * 1-Methyl-1,6-dihydro-2-pyridinecarboxaldehyde oxime hydrochloride
   * Pro-Pam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 173 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   47,305,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 168 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   47,305,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   47,305,1979
 
                            *** END OF RECORD ***