*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TI5609710
CHEMICAL NAME           : Phthalimide,
                          N-(1-(morpholinomethyl)-2,6-dioxo-4-piperidyl)-
CAS REGISTRY NUMBER     : 10329-96-1
BEILSTEIN REFERENCE NO. : 1170135
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C18-H19-N3-O5
MOLECULAR WEIGHT        : 357.40
WISWESSER LINE NOTATION : T56 BVNVJ C- ET6VNVTJ B1- AT6N DOTJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * CG 603
   * E-352
   * 1H-Isoindole-1,3(2H)-dione,  
   2-(1-(4-morpholinylmethyl)-2,6-dioxo-4-piperidinyl)-
   * 1-Methyl-morpholino-4-phthalimido-glutarimide
   * N-(1-(Morpholinomethyl)-2,6-dioxo-4-piperidyl)phthalimide
   * Morpholino-beta-thalidomide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 194,39,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1620 mg/kg
TOXIC EFFECTS :
   Endocrine - changes in luteinizing hormone
   Endocrine - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 194,39,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >8 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 194,39,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4250 mg/kg
TOXIC EFFECTS :
   Endocrine - changes in luteinizing hormone
   Endocrine - other changes
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 194,39,1971
 
                            *** END OF RECORD ***