*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TI3150000
CHEMICAL NAME : Phthalic anhydride
CAS REGISTRY NUMBER : 85-44-9
LAST UPDATED : 199712
DATA ITEMS CITED : 48
MOLECULAR FORMULA : C8-H4-O3
MOLECULAR WEIGHT : 148.12
WISWESSER LINE NOTATION : T56 BVOVJ
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
Primary Irritant
SYNONYMS/TRADE NAMES :
* Anhydride phtalique
* Anhydrid kyseliny ftalove
* Anidride ftalica
* 1,2-Benzenedicarboxylic acid anhydride
* 1,3-Dioxophthalan
* ESEN
* Ftaalzuuranhydride
* Ftalanhydrid
* Ftalowy bezwodnik
* Isobenzofuran, 1,3-dihydro-1,3-dioxo-
* 1,3-Isobenzofurandione
* NCI-C03601
* Phthalandione
* 1,3-Phthalandione
* Phthalic acid anhydride
* Phthalic anhydride
* Phthalsaeureanhydrid
* RCRA waste number U190
* Retarder AK
* Retarder PD
* Vulkalent B
*** HEALTH HAZARD DATA ***
** SKIN/EYE IRRITATION DATA **
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 500 mg/24H
REACTION SEVERITY : Mild
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 13-4/1970
TYPE OF TEST : Standard Draize test
ROUTE OF EXPOSURE : Administration into the eye
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 50 mg/24H/MOD
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 15(Suppl 1),S68,1996
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1530 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-
1990- Volume(issue)/page/year: 15(Suppl 1),S68,1996
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >210 mg/m3/1H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 13-4/1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
GKNT, 1982 Volume(issue)/page/year: -,100,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,322,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810
Frontage Rd., Northbrook, IL 60062) Volume(issue)/page/year: 13-4/1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH,
Chemical Rubber Co., 1968 Volume(issue)/page/year: -,410,1968
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/m3/2H/2W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Liver - other changes
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 2,59,1961
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 6 gm/kg/42D-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - gastritis
Gastrointestinal - other changes
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 2,59,1961
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 1 mg/m3
SEX/DURATION : male 45 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
sperm morphology, motility, and count)
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 35(1),105,1970
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE : 203 mg/kg
SEX/DURATION : female 8-10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
REFERENCE :
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc.,
41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year:
2,61,1982
** MUTATION DATA **
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 3 mmol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
24,181,1994
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 6.1 mg/m3 (1 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
BPCT** Progress Report from the Environmental Protection Agency to NIOSH on
Benzenepolycarboxylates, 1974 Volume(issue)/page/year: -,183,1974
TOXICOLOGY REVIEW
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing
Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
Volume(issue)/page/year: 4,3,1973
TOXICOLOGY REVIEW
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge
des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
Volume(issue)/page/year: 10(3),49,1973
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 2 ppm (12 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,212,1971
OSHA PEL (Gen Indu):8H TWA 2 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 2 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 2 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 2 ppm (12 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993
OEL-BELGIUM:TWA 1 ppm (6.1 mg/m3) JAN 1993
OEL-DENMARK:TWA 5 mg/m3 JAN 1993
OEL-FINLAND:TWA 2 mg/m3;STEL 3 mg/m3;Skin JAN 1993
OEL-FRANCE:STEL 6 mg/m3 JAN 1993
OEL-GERMANY:TWA 5 mg/m3 JAN 1993
OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993
OEL-POLAND:TWA 1 mg/m3 JAN 1993
OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993
OEL-SWEDEN:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 0.8 ppm (5 mg/m3);STEL 1.6 ppm (10 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3);STEL 4 ppm (24 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO PHTHALIC ANHYDRIDE-air:10H TWA 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 59230
No. of Facilities: 10056 (estimated)
No. of Industries: 128
No. of Occupations: 90
No. of Employees: 134716 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 59230
No. of Facilities: 5265 (estimated)
No. of Industries: 72
No. of Occupations: 67
No. of Employees: 81312 (estimated)
No. of Female Employees: 14675 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat
NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
(Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
Volume(issue)/page/year: NCI-TR-159,79
*** END OF RECORD ***