*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : TD5175000
CHEMICAL NAME : Phosphorodithioic acid,
S-((6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl)
O,O-diethyl ester
CAS REGISTRY NUMBER : 2310-17-0
OTHER CAS REGISTRY NOS. : 54182-71-7
BEILSTEIN REFERENCE NO. : 0694650
LAST UPDATED : 199806
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C12-H15-Cl-N-O4-P-S2
MOLECULAR WEIGHT : 367.82
WISWESSER LINE NOTATION : T56 BNVOJ B1SPS&O2&O2 GG
COMPOUND DESCRIPTOR : Agricultural Chemical
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Azofene
* S-((3-Benzoxazolinyl-6-chloro-2-oxo)methyl) O,O-diethyl
phosphorodithioate
* Benzphos
* Benzophosphate
* Chipman 11974
* S-(6-Chloro-3-(mercaptomethyl)-2-benzoxazolinone) O,O-diethyl
phosphorodithioate
* 3-(6-Chloro-2-oxobenzoxazolin-3-yl)methyl O,O-diethyl
phosphorothiolothionate
* S-((6-Chloro-2-oxo-3(2H)-benzoxazolyl)methyl) O,O-diethyl
phosphorodithioate
* O,O-Diaethyl-S-(6-chlor-benzoxazolon-2-on-3-yl)-dithiophosphat
* O,O-Diaethyl-S-(6-chlor-2-oxo-ben(b)-1,3-oxalin-3-yl)-methyl-dithiophosp
hat
* O,O-Diethyl-S-((6-chloor-2-oxo-benzoxazolin-3-yl)-methyl)-dithiofosfaat
* O,O-Diethyl S-(6-chlorobenzoxazolinyl-3-methyl) dithiophosphate
* O,O-Diethyl S-((6-chloro-2-oxobenzoxazolin-3-yl)methyl)
phosphorodithioate
* O,O-Diethyl-S-(6-chloro-2-oxo-benzoxazolin-3-yl)methyl-phosphorothioloth
ionate
* 3-Diethyldithiophosphorylmethyl-6-chlorobenzoxazolone-2
* O,O-Diethyl phosphorodithioate, S-ester with
6-chloro-3-(mercaptomethyl)-2-benzoxazolinone
* O,O-Dietil-S-((6-cloro-2-oxo-benzossazolin-3-il)-metil)-ditiofosfato
* ENT 27,163
* Fosalon
* NIA-9241
* Niagara 9241
* NPH-1091
* P-974
* Phosalon
* Phosalone
* Phosphorodithioic acid-S-ester of
6-chloro-3-mercaptomethylbenzoxazyol-2-one
* Rhodia RP 11974
* RP 11,974
* Rubitox
* Zolon
* Zolone
* Zolone PM
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
Volume(issue)/page/year: 16(2),59,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 390 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71.
Discontinued. Volume(issue)/page/year: 9,119,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,371,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 73 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 19(9),55,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - cat
DOSE/DURATION : 112 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, 1957-1992. For publisher information, see MTPEEI
Volume(issue)/page/year: 14(12),46,1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel,"
Perkow, W., Berlin, Verlag Paul Parey, 1971-1976 Volume(issue)/page/year:
-,-,1971/1976
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada,
171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,408,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - chicken
DOSE/DURATION : 661 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1924- Volume(issue)/page/year: 54(11),75,1978
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 400 mg/kg
TOXIC EFFECTS :
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
IJTHEZ International Journal of Toxicology, Occupational and Environmental
Health. (Wiley Eastern, 4835/24 Ansari Road, Daryaganj New Delhi 110002,
India) V.1- 1991- Volume(issue)/page/year: 1,186,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 803 mg/kg/17W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), zonal
Liver - other changes
Vascular - structural changes in vessels
REFERENCE :
EKMMA8 Eksperimentalna Meditsina i Morfologiya. (Hemus, Blvd. Russki 6,
Sofia, Bulgaria) V.1- 1962- Volume(issue)/page/year: 18,177,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 262 mg/kg/3W-I
TOXIC EFFECTS :
Liver - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 44,126,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 524 mg/kg/26W-I
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - catalases
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 50(2),73,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8925 mg/kg/2Y-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Blood - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
36,561,1976
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 515 ug/kg/24H/92D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 41(7),10,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 3640 mg/kg/2Y-C
TOXIC EFFECTS :
Blood - other changes
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
36,561,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 264 mg/kg
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno
Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1-
1975- Volume(issue)/page/year: 2,169,1976
*** REVIEWS ***
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
63,1,1976
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year:
54,7740,1989
*** STATUS IN U.S. ***
On EPA IRIS database
*** END OF RECORD ***