*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : TC2509000
CHEMICAL NAME           : Phosphoric acid,
                          (3-(dimethylamino)-1-hydroxypropylidene)bis-,
                          disodium salt
CAS REGISTRY NUMBER     : 121368-58-9
LAST UPDATED            : 199603
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C5-H13-N-O7-P2.2Na
MOLECULAR WEIGHT        : 307.11
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Dimethyl APD
   * Disodium (3-(dimethylamino)-1-hydroxypropylidene)bisphosphate
   * IG 8801
   * Olpadronate sodium
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32400 mg/kg/27W-I
TOXIC EFFECTS :
   Musculoskeletal - other changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   BONEDL Bone. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY  10591)
   V.6-    1985-  Volume(issue)/page/year: 16,285S,1995
 
                            *** END OF RECORD ***